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The toxicology of Butea superba, Roxb.

 

Source:  Southeast Asian J Trop Med Public Health.  2002; 33 Suppl 3:155-8 (ISSN: 0125-1562)

Pongpanparadon A; Aritajat S; Saenphet K

Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand.

 

A study to determine the primary toxicological effects of Red Kwao Krua (Butea superba, Roxb.) dry powder by micronucleus and dominant lethal tests was undertaken. Aqueous solution of Red Kwao Krua dry powder in doses of 2, 20, 200 and 1,000 mg/kg/day were fed to male rats for 9 weeks. The results showed that 1,000 mg/kg/day of Red Kwao Krua solution was significantly more effective in inducing the formation of micronuclei in polychromatic erythrocytes than the control (p<0.01), whereas dominant lethal test indicated that none of the doses had a toxic effect on male reproduction. There were no abnormal changes in the number of implantation sites and the number of dead fetuses produced by females that had mated with Red Kwao Krua treated males in comparison with the controls. In addition, the Red Kwao Krua solutions had no effect on the body weights of the treated rats.

 

The authors believe that Butea superba may act primarily by increasing the relaxation capacity of the corpus cavernosum smooth muscles via cAMP phosphodiesterase inhibition [7] and may also affect the brain, triggering the improvement of the emotional sexual response. It is interesting to note that patients with additional health problems, such as diabetes mellitus, hyper-tension, heart disease and hyperthyroidism, responded satisfactorily to Butea superba.

 

Butea superba’s mechanism is very similar to sildenafil (Viagra) and that Butea superba is called “the Herbal Viagra”

 

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