Pueraria mirifica prevents bone loss ii
Bone loss is one major menopause symptom. Pueraria mirifica improves bone loss caused by estrogen deficiency.
J Reprod Dev. 2004 Dec;50(6):639-45.
Long-term treatment effects of Pueraria mirifica phytoestrogens on parathyroid hormone and calcium levels in aged menopausal cynomolgus monkeys.
Trisomboon H, Malaivijitnond S, Suzuki J, Hamada Y, Watanabe G, Taya K.
Biological Science Ph.D. Program, Faculty of Science, Chulalongkorn University, Bangkok, Tokyo, Japan.
PMID: 15647615 [PubMed – indexed for MEDLINE]
To determine the effect of Pueraria mirifica (PM) on serum parathyroid hormone (PTH) and calcium levels on aged menopausal monkeys (Macaca fascicularis), subjects were treated with 10, 100, or 1,000 mg/day of PM. Blood samples were collected every 5 days for 30, 90, and 60 days during pre-treatment, treatment, and post-treatment periods, respectively. Sera were assayed for PTH, estradiol, and calcium levels. PM-1,000 had the strongest effect on the decrease in PTH (0.001The results suggest that long-term treatment with 1,000 mg/day of Pueraria mirifica decreases serum PTH and calcium levels in aged menopausal monkeys, indicating that Pueraria mirifica ameliorates bone loss caused by estrogen deficiency.
Pueraria mirifica studies
Efficacy comparison of Pueraria mirifica (PM) against conjugated equine estrogen (CEE) with/without medroxyprogesterone acetate (MPA) in the treatment of climacteric symptoms in perimenopausal women: phase III study
The effect of Pueraria mirifica on cytologic and urodynamic findings in ovariectomized rats.Effects and safety of Pueraria mirifica on lipid profiles and biochemical markers of bone turnover rates in healthy postmenopausal women.
Challenges in the conduct of Thai herbal scientific study: efficacy and safety of phytoestrogen, pueraria mirifica (white kwao krua) phase I, in the alleviation of climacteric symptoms in perimenopausal women.