Pueraria mirifica Studies ii
Pueraria mirifica reduce Breast cancer risks
Source: Medical Plant Research Institute Department of Medical Sciences, Ministry of Public Health, Thailand.
A series of pueraria mirifica studies involving breast cell lines and the activity of Pueraria mirifica in vitro have been performed by the Emory University School of Medicine in Atlanta, Georgia, USA, and the Department of Obstetrics and Gynecology, Phramongkutklao College of Medicine, Bangkok, Thailand. These studies have shown that Pueraria mirifica root extract has potent anti-estrogenic properties against aggressive cell cancer lines in vitro, especially the proliferative estrogen receptor-positive estrogen receptor-positive (ER+) breast cancer lines (T47-D, MCF-7, and ZR-75-1) obtained from the MD Anderson Cancer Institute (Texas) and the National Cancer Institute (NCI) at the U.S. National Institutes of Health (NIH).
Pueraria mirifica promotes fibroblasts in normal breast cells and inhibits estrogen-dependent breast cancer cells. Unpublished, 2001, Sawatsri, S., Juntayanee, B., Jitpatima, S., Boonnao, P., Kampoo, C., Ayuttaya, N., Wongyai, S. and Sidell, N.
According to the pueraria mirifica studies conducted at the School of Medicine, Saint Mariane University, Tokyo, Japan by Kuramoshi, T. and Smitasiri, Y. about the preliminary study of Pueraria mirifica in Japanese females, 50 healthy menstruating volunteer females, ages 20 to 49, were given between 100 to 600 mg orally of Pueraria mirifica root powder daily as capsules for 7 days, two weeks after menstruation. No reports of abnormally heavy, severe, or missed menstruation were recorded.
Animal Test: There were reports during the year 1960-61 from the British researchers to test the effects of miroestrol; the key chemical from this herb in the ovariectomized and the premature female rats. The results showed the estrogenic effects of this chemical. It implied that the sythetic estrogen or animal estrogen or even human estrogen could be substituted by this chemical.
Human Test: Miroestrol has also been tested in human and was reported in 1961 as a potent estrogen effect. The Thai medical doctor has tested the crude extract in the patients in the year 1941. The result also showed the promising application of this herb.
Skin Test: Six female albino rats were hair cut and injected with 0.1% of Pueraria mirifica extract. The test was completed and showed no allergic to skin. It implied that the dermal diffsion did not cause any dermal irritation to the skin. Thus, the Pueraria mirifica extract can be presented in the cosmetics without any allergic effect.
Pueraria mirifica Studies and Reseach
It has been revealed recently that Pueraria mirifica is safe to be used in human in certain dosage as well as consumption period. The researcher has been conducting a series of researches covering the chemical analysis, tissue culture, mass propagation, cultivar improvement, production, product development and testing and so on for 9 years.
The result shows that Pueraria mirifica contains very high isoflavone content and shows high antimutagenic effects as well as high killing effects to human mammary cancer cell line. Nowadays, nutritionists recommend the consumer to consume isoflavone regularly for the purpose of cancer protection normally found on post-menopausal and people who have hormone imbalance.
The Benefits of Miroestrol and Its Derivatives in Pueraria mirifica Miroestrol and its derivatives are also precious chemicals in the white kwao krau which promote estrogenic and mammogenic effects to various tissues such as breast enlargement or breast tissue reformation.
The Differences between Soya and Pueraria mirifica
Soya, the western health food products, contains lower amount of phytoestrogens especially there is no miroestrol and its derivatives. Their benefit to the body is far less than that of Pueraria mirifica. The researches confirm that these chemicals are potent anti-breast cancer, anti-prostate hyperplasia, anti-colon cancer, anti-osteoporosis and also anti-cardiovascular disease via the potent reduction of blood cholesterol and also anti-menopausal syndrome.
Upside down, it says there is no danger as feared. Moreover, it takes effect preventing chest cancer and in addition helps build brain cells, capable of preventing Alzheimer’s disease.
A national – level committee is set up to push for export – processing.
Dr. Suraphong Suepwongli the Deputy Minister of Public Health, has said that the Ministry of Public Health (MOPH) convened a meeting of the Pueraria mirifica study working group on August 27 , at which the relevant researchers from various agencies and institutes were present, such as from Chulalongkorn University , the National Cancer Institute, the Institute of Dermatiology, the Department of Medical Sciences, Mae Fa Luang University, etc., to determine a way to promote use of Pueraria mirifica as raw-material in a topping industry with a view to commercialized distribution, which, so far as the discussion is concerned, can be summed up that researcher from several institutes find that Pueraria mirifica is clinically effective for use as a substitute for hormone in menopause women and there is a trend that it will be used to enlarge the breast, including curing Alzheimer’s disease, because research findings several that it can generate a regrowth of brain cells.
“As regards long-term toxicity, 2-3 years ago there were researchers studying about Pueraria mirifica to the extent of making spreading news, causing the MOPH experts to worry very much that consumption might lead to long-term toxicity causing breast cancer. At this meeting it was acknowledged that the National Cancer Institute, which had experimented for a period, obtained a conclusion that said Pueraria mirifica is non-carcinogenic and this conforms to the research of King Mongkut’s Hospitat which found and opposite outcome, i.e. Pueraria mirifica, on the contrary, has an effect capable of also preventing chest cancer,” Dr. Suraphong said.
Pueraria mirifica studies
Efficacy comparison of Pueraria mirifica (PM) against conjugated equine estrogen (CEE) with/without medroxyprogesterone acetate (MPA) in the treatment of climacteric symptoms in perimenopausal women: phase III study
The effect of Pueraria mirifica on cytologic and urodynamic findings in ovariectomized rats.Effects and safety of Pueraria mirifica on lipid profiles and biochemical markers of bone turnover rates in healthy postmenopausal women.
Challenges in the conduct of Thai herbal scientific study: efficacy and safety of phytoestrogen, pueraria mirifica (white kwao krua) phase I, in the alleviation of climacteric symptoms in perimenopausal women.